阻塞性睡眠呼吸暂停低通气综合征与促红细胞生成素相关性研究

Study of correlation between obstructive sleep apnea-hypopnea syndrome and erythropoietin

目的:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清促红细胞生成素(EPO)水平及与UPPP的疗效的相关性。方法:59例OSAHS患者行UPPP,测量咽腔术前术后改变;测定OSAHS患者术前、术后及38例对照组的血清EPO水平;观察各测量值的变化。结果:OSAHS患者手术前后颈围、AHI、SaO2、BMI、腭舌弓间距、悬雍垂与咽后壁间距、软腭长度、悬雍垂长度、口咽部最小截面积比较均差异有统计学意义(均P<0.01);术前上述测值与对照组比较均差异有统计学意义(均P<0.01),术后颈围、BMI、口咽部最小截面积与对照组比较均差异有统计学意义(均P<0.05),而腭舌弓间距、悬雍垂与咽后壁间距、软腭长度、悬雍垂长度与对照组比较均差异无统计学意义(均P>0.05)。OSAHS患者EPO水平手术前后比较差异有统计学意义(P<0.01);术后与对照组比较EPO水平差异无统计学意义(P>0.05)。结论:OSAHS患者血清EPO水平较对照组偏高,并与睡眠呼吸暂停的程度有关。UPPP是有效的OSAHS治疗手段,治疗有效者血清EPO水平降低。

Objective：To investigate the effect of uvuplopalatopharyngoplasty on change of serum erythropoietin levels in patients with obstructive sleep apnea-hypopnea syndrome （OSAHS） treatment. Method： Fifty-nine patients with OSAHS were treated through uvuplopalatopharyngoplasty. Observing follow indexes of pre and postoperation： pharyngeal space, neck size. Pre and post-operative serum erythropoietin levels were detected. Result： Neck size, AHI, BMI, SaO2, distance between anterior pillars, distance between uvula and posterior wall, length of palatum, length of uvula and minimum secar of pharynx oralis in preoperative patients were significant higher than those in postoperative patients （P〈0.01）. Neck size, BMI and minimum secar of pharynx oralis in postoperative patients were significant higher than those in normal adults （P〈0.01） There were no significant difference between postoperative patients and normal adults in distance between anterior pillars, distance between uvula and posterior wall, length of palatum,length of uvula （P〉0.01）. The level of EPO in preoperative patients were significant higher than that in postoperative patients （P〈0.01）. There was no significant difference between postoperative patients and normal adults in the level of EPO （P〉0.01）. Conclusion：The level of EPO in OSAHS patients is higher than that in normal adults. It was correlative with AHI. The uvuplopalatopharyngoplasty was efficacious in treatment of OSAHS. The levels of EPO were decreased through efficacious treatment.