复发性缺血性脑卒中危险因素的研究

Risk Factors of Recurrent Ischemic Stroke

为探讨影响缺血性脑卒中复发的危险因素，采用以医院为基础的队列研究，对近５年缺血性脑卒中住院病人７７４例进行随访调查，经ＣＯＸ比例风险模型分析，结果显示：糖尿病史（ＲＲ：３．１６，Ｐ＜０．００１）、家族卒中史（ＲＲ：１．５５，Ｐ＜０．０５）、阿司匹林服用情况（ＲＲ：２．３８，Ｐ＜０．００１）及血压控制情况（ＲＲ：１．５９，Ｐ＜０．００１）为影响复发的独立危险因素。提示在缺血性脑卒中二级预防工作中，可将糖尿病史及家族卒中史作为识别高危复发人群的重要标志，病后长期服用阿司匹林及规律服用降压药是预防复发有效的干预措施。

A hospital based cohort study was conducted to investigate the risk factors of rucurrent ischemic stroke.774 in patients of ischemic stroke were followed up in 1991￣1996.The results showed that 112 cases were recurrent.There were four independent risk factors of ischemic stroke by Cox proportional hazards analysis,which were the history of diabetes(RR:3.16, P <0 001),the familiar stroke history (RR:1 55, P <0 05),history of taking Aspirin after primary stroke (RR:2 38, P <0 001),and poor control of blood pressure after first stroke(RR:1 59, P <0 001).