铅致心肌细胞死亡率与锌对其改变影响的研究

Lead induced Mortality in Myocardial Cell and Influence of Zinc on Changes

铅致心肌细胞死亡率与锌对其改变影响的研究山西医科大学劳动卫生学教研室（太原０３０００１）李金有北京医科大学劳动卫生学教研室刘世杰近年，许多研究表明，铅可对心脏产生毒性作用，且主要是通过间接作用所致［１，２］。鉴于铅不仅是一严重的职业危害，亦是一严重...

Myocardial cell culture was applied to explore the lead induced changes in myocardial cell mortality and contraction and the influences of zinc.The results were as follows:lead in the dose range of 1～100μmol had no effect on the cell mortality.However,lead in the same range could affect the cell contraction.Compared to control group,in 10μmol/L group the beat peaked,then began to drop with the increase in the dose of lead,a lowest beat appeared in 100μmol/L group.Zinc at dose of 5μmol/L could protect the myocardia cell against lead induced abnormal contraction.Thus,it follows that lead has no effect on the myocardia cell mortality but can affect the contraction and that zinc might protect the cells against lead induced abnormal contraction to a certain extent.