动脉硬化性血栓性脑梗塞患者红细胞膜钙泵活性与血流动力学研究

Study on activity of calcium pump in erthrocytic membrane and hemodynamics in patients with atherothrombotic cerebral infarction

本文对３２例动脉硬化性血栓性脑梗塞（ＡＴＣＩ）患者进行了红细胞膜Ｃａ２＋Ｍｇ２＋－ＡＴＰ酶、全血粘度（ＷＶ）与局部脑血流（ｒＣＢＦ）量的检测，并与３０例健康对照组进行了比较。结果患者组的Ｃａ２＋Ｍｇ２＋－ＡＴＰ酶、ｒＣＢＦ均明显低于对照组（Ｐ＜０．０１～０．００１），ＷＶ明显高于对照组（Ｐ＜０．０１）。患者组的Ｃａ２＋Ｍｇ２＋－ＡＴＰ酶活性与ｒＣＢＦ相关分析呈显著正相关，与ＷＶ比较两者呈明显负相关。提示钙泵活性与血流动力学的检测对ＡＴＣＩ患者的治疗和预后均有重要意义。

Ca^2+ Mg^2+ATP enzyme in erythrocytic membrane,whole blood viscosity(WV) and regional cerebral blood flow(rCBF) were seperately measured in 32 patients with ATCI and in 30 normal controls.The results showed that Ca^2+ Mg^2+ATP enzyme ,rCBF were obviously lower in patients than in controls(P<0.01～0.001),but WV was obviously higher in patients;the activity of Ca2+Mg2+ATP enzyme had significant positive relationship with rCBF,had obvious negative relationship with WV.They suggested that study on activity of calcium pump and hemodynamics had important significance in prophylaxis and therapy in ATCI.