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在细胞膜水平提高5-FU在胰腺癌细胞中的浓度

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摘要 胰腺癌发现时往往已属晚期．虽采用以手术为主的综合治疗，但预后极差。5-FU是常用的化疗药物，但疗效不佳。5-FU在细胞内代谢为一磷酸脱氧核糖氟尿嘧啶核苷（FdUMP）和三磷酸氟尿嘧啶核苷（FUTP）后产生细胞毒性．因此增加细胞内5-FU的浓度将能增强其化疗效果。
作者 王晶敏 陈建华 缪云翔
机构地区 苏州市立医院北区普外科
出处 《外科理论与实践》 2008年第1期67-68,共2页 Journal of Surgery Concepts & Practice
关键词 胰腺肿瘤 氟尿嘧啶 核苷类 药物载体
分类号 R735.9 [医药卫生—肿瘤]
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参考文献9

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2008年 第1期

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