辛伐他汀对高糖刺激下系膜细胞细胞骨架及结缔组织生长因子mRNA表达的影响
被引量：1
摘要
他汀类药物属羟甲基戊酰酶A（HMG-CoA）还原酶抵制剂，不仅具有降脂作用，同进还有一定的非降脂相关的肾保护作用^[1]。结缔组织生长因子（CTGF）是促进肾脏纤维化的重要因子。肌动蛋白细胞骨架介导了细胞许多的生物学功能。本实验采用体外技术直接观察高糖对系膜细胞骨架及CTGF mRNA表达的影响以及辛伐他汀对其的作用，并探讨相关机制。
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
2008年第3期204-205,共2页
Chinese Journal of Nephrology
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