大肠癌中医辨证分型与病理组织学的相关性研究

Comparative Study between the differentiation of TCM Syndrome and histopathology in Moderate-late Stage colorectal cancer

目的:研究中晚期大肠癌中医辨证分型与病理组织学的相关性。方法:对中晚期大肠癌患者进行辨证分型,并检测病理组织学类型,对两者的相关性进行分析。结果:大肠癌病理类型及临床分期与中医证型相关(P<0.001),中分化腺癌以脾肾阳虚型为主;低分化腺癌以肝肾阴虚型为主;乳头状腺癌及粘液腺癌以气血两虚型为主。早期实证多于虚证,晚期虚证多于实证。结论:中晚期大肠癌中医辨证分型具有相关的病理组织学特征。

Objective. Probe into the relationship between TCM syndromes and histopathology in Moderate-late Stage colorectal cancer. Methods.Colorectal cancer patients were divided into several differentiations of symptoms and signs, and were detected pathologic type. Results. TCM syndromes in different histologic classification is significant with statistical analysis（P 〈 0. 001 ）. The type of deftciency of both spleen and kidney is more common in middle differentiation adenocarcinoma; the type of deficiency of both hepatic and kidney is more common in poor differentiation adenocarcinoma; the type of deficiency of both QI and blood is more common in papillary and mucous adenocarcinoma, The excess-syndrome is more common in Dukes,A; the deficiency- syndrome is more common in late Stage. Conclusion： TCM differentiations of syndromesin Moderate-late Stage colorectal cancer have relations with histopathology.