消风散颗粒对肥大细胞脱颗粒的抑制作用

The Restrain Influence of Xiaofengsan on Mast Cells Degranulation

目的:探明消风散的抗变态反应的作用。方法:通过对大鼠颅骨骨膜肥大细胞脱颗粒的影响,观察消风散抗变态反应的作用及强度。结果:5.2g/kg和3.9g/kg剂量组消风散对大鼠颅骨骨膜肥大细胞脱颗粒的抑制率分别为(52.90±1.95)%和(46.25±2.96)%。结论:消风散能明显抑制大鼠颅骨骨膜肥大细胞脱颗粒,说明其有抗变态反应作用,为该药治疗荨麻疹提供了理论依据。

Objective：To explore the antiallergic effect of Xiaofengsan. Method By surveying the influence of Xiaofeng^n to rat skull periast mast cells degranulation, study the antiallergic effect and active strength of Xiao-feng-san. Result： The inhibition ratio of Xiao- feng-san to rat skull periost mast cells degranulation： 5.2 g/kg dose group （52.90 ± 1.95） %, 3.9g/kg dose group （46.25 ± 2. 96） %. Conclusion： Xiaofengsan notable inhibition to rat skull periost mast cells degranulation had proved its antiallergic effect, and provided theoretical base of its application to allergic rhinitis.