心脉隆注射液药理作用和治疗心力衰竭临床研究进展

Cardiovascular action and therapeutic effect of Xinmailong injection for treating heart failure

心脉隆注射液是治疗心衰的新药,其有效成份为多肽、核苷及复合氨基酸等。体内外研究表明其对心血管系统具有多方面的作用:促进心肌细胞Ca2+内流,温和持久地增加心肌收缩力;扩张冠脉、增加冠脉血流量,抑制氧自由基介导的心肌损伤;扩张血管,降低肺动脉压、肺毛细血管内压、体动脉压;纠正神经内分泌失衡,增加血浆降钙素基因肽(CGRP)含量,抑制内皮素(ET)的分泌和作用;扩张肾血管,增加肾血流量、利尿;防治心律失常。临床应用于各种原因所致心力衰竭患者。文中综述其药理作用和治疗心力衰竭临床研究进展。

Xinmailong （XML） injection is a new kind of therapeutic agents for heart failure that came into market in 2006. Its active constituents include polypeptides, nucleosides, and aminofusins. A lot of in vivo and in vitro studies show that XML injection has various effects on cardiovascular activity, such as increasing the free Ca^2＋ content in myocardial ceils, hence enhancing myocardial contractility persistently and gently; dilating coronary arteries to increase coronary flow ; inhibiting the myocardial damage induced by oxygen free radicals ; declining pulmonary pressure, pulmonary capillary pressure and systemic arterial pressure ; correcting neuroendocrine disorders such as increasing calcitonin gene related protein （CGRP） content and inhibiting the secretion and function of endothelin （ET） ; dilating vessels of kidney to increase the renal blood flow and diuresis ; and preventing arhythmia. Clinically, Xinmailong injection is an effective and safe drug for heart failure without obvious side effects, providing the patients with a new optional treatment.