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SARA、TGF-β/Smad信号通路与腹膜纤维化的基因治疗 被引量：1

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摘要 长期腹膜透析可导致腹膜纤维化,其主要特征是间皮细胞剥落和细胞外基质（ECM）的异常积聚所致的腹膜增厚,使腹膜透析效率降低。腹膜纤维化的产生是多种因素作用的结果,多种促纤维化细胞因子具有重要的调节作用,其中作用最为关键的是转化生长因子-β1（TGF-β1）。最近的研究显示,
作者 凌光辉 刘伏友
机构地区 中南大学肾脏病研究所中南大学湘雅二医院肾内科
出处 《中国血液净化》 2008年第3期153-155,162,共4页 Chinese Journal of Blood Purification
基金 国家自然科学基金资助项目(30370811)
关键词 腹膜纤维化 TGF-Β SMAD信号通路 SARA 基因治疗 转化生长因子-β1 促纤维化细胞因子 长期腹膜透析
分类号 R459.5 [医药卫生—治疗学] R683 [医药卫生—骨科学]
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同被引文献17

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中国血液净化
2008年 第3期

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