中期因子基因在疾病诊断和治疗中的应用

Application of Midkine Gene in Diagnosis and Therapy

中期因子(midkine,MK)是一种肝素结合生长因子。与炎性疾病、肿瘤、神经病变性疾病及AIDS的发生有着重要的关系。MK在多种实体肿瘤中有高表达,可以作为肿瘤的预后指标以及多种疾病治疗的靶点。针对MK的治疗主要是应用MK的抗体、反义寡核苷酸、siRNA和一些能够与MK发生特异结合分子,其作用机制主要是抑制MK生成以及中和MK作用。作为一种肿瘤特异性启动子,MK启动子调控自杀基因也被应用于肿瘤的治疗。

Midkine （MK）, a heparin-binding growth factor, plays an important role in the pathogenesis of tumor, inflammation, neurodegenerative diseases and the development of AIDS. MK can be used as a novel tumor marker and therapeutic target. As a tumor-specific promoter, MK promoter regulating suicide gene expression is efficient and specific in tumor therapy.