真核翻译起始因子4E

Eukaryotic Initiation Factor 4E

在细胞质中,真核起始因子4E(eukaryotic initiation factor 4E,eIF4E)能通过与mRNA5′端帽子结构结合,在蛋白质翻译起始过程中起重要作用。在细胞核中,eIF4E能促进一些mRNAs从细胞核转运到细胞浆。eIF4E是一原癌基因,与细胞的转化、凋亡耐受、创伤的愈合和寿命的延长有关。eIF4E的生物学活性受到eIF4E结合蛋白、自身磷酸化、早幼粒细胞白血病蛋白和同源结构域蛋白等的调节。eIF4E能通过泛素-蛋白酶体途径降解。大量数据显示,eIF4E是肿瘤靶向治疗的一个位点,然而到目前为止还没有一个肿瘤特异的eIF4E靶向治疗药物用于临床。

In the cytoplasm, eIF4E plays an important role in the initiating process of protein translation through its interaction with the 5′ cap structure of mRNA. In the nucleus, eIF4E facilitates nuclear export of a subset ofmRNAs, eIF4E is considered to be a oncogene protein involved in cell transformation, apoptotic resistance, wound healing, and the extended lifes pan. eIF4E activity is regulated by eIF4E binding proteins （4E-BPs）, direct phosphorylation, promyelocytic leukemia protein PML and homeodomain protein, eIF4E can be digested by the proteasome-dependent proteolysis. A wealth of data has suggested that eIF4E could serve as a potential anti-cancer therapeutic target. So far, no eIF4E-specific therapy has been clinically used.