Annexin A2的结构和功能及其与疾病的关系

Annexin A2:Structure,Function and Association with Diseases

Annexins是一类钙依赖性膜磷脂结合蛋白。Annexin A2是Annexins家族中的一个重要成员,存在于细胞膜、胞质和胞外。Annexin A2蛋白在细胞膜构架的形成、膜聚合、内吞和胞吐中均扮演重要角色。Annexin A2还参与某些病理过程,与心血管疾病、血液病、肿瘤等多种疾病相关。文章简要综述了Annexin A2分子的结构、生化特征、生物学功能及其与疾病的关系。

Annexins are a kind of calcium-dependent, membrane-phospholipid binding proteins. Annexin A2 belongs to the family of Annexins, which exists as either a membrane-associated, cytosolic or soluble form in serum. Annexin A2 can act as a membrane scaffold protein, and is involved in membrane organization, membrane fusion, endocytosis and exocytosis. It also partakes in some pathological processes and is associated with cardiovascular diseases, leukemia and cancer, etc. This article briefly reviews the structure and function of Annexin A2 and its association with diseases.