摘要
E-cadherin是介导上皮细胞间粘附的一种粘附分子,其功能异常与肿瘤的浸润和转移密切相关。乳腺肿瘤中,E-cadherin表达缺失或下降,在肿瘤的浸润转移过程中起着非常重要的作用。基因突变、基因启动子区甲基化或转录抑制等是E-cadherin表达异常的原因。
E -cadherin is amolecule involved in epithelial cell adhesion has close relationship with. Down - regulation or complete loss of E - cadherin expression has been found to correlate with invation and metastasis in breast cancers. Gene mutation, methylated gene promoter, or transcription repression are considered the possible mechanism of the inactivation of E - cadherin.
出处
《癌症进展》
2008年第2期135-140,共6页
Oncology Progress
