β1，4-N-乙酰半乳糖胺转移酶的表达调节及其在检测肿瘤微转移中的应用研究
摘要
β1,4-N-乙酰半乳糖胺转移酶是糖基转移酶的家族成员之一,它是神经节苷脂GM_2、GD_2以及糖脂GA_2合成的关键酶。目前,动物模型研究结果表明,该酶在神经组织的维持与修复、精母细胞的分化以及白细胞介素-2受体复合体的调节等方面具有重要的作用。它在许多恶性肿瘤组织和细胞株中表达增加,与肿瘤的发生发展密切相关,近年来,应用该酶检测肿瘤微转移已经引起肿瘤学界的重视。
出处
《癌症进展》
2008年第2期157-162,共6页
Oncology Progress
参考文献33
-
1[1]Livingston P.Ganglioside vaccines with emphasis on GM2.Semin Oncol,1998,25(6):636
-
2[2]Bitton RJ,Cuthmann MD,Cabri MR,et al.Cancer vaccines:An update with special focus on ganglioside antigens.Oncol Rep,2002,9(2):267
-
3[3]Shepherd FA.Alternatives to chemotherapy and radiotherapy in the treatment of small cell lung cancer.Semin Oncol,2001,28(2 Suppl 4):30
-
4[4]Ruan S,Raj BK,Furnkawa K,et al.Analysis of melanoma cells stably transfected with beta 1,4GalNAc transferase(GM2/GD2 synthase)cDNA:relative glycosyltransferase levels play a dominant role in determining ganglioside expression.Arch Biochem Biophys,1995,323(1):11
-
5[5]Yamashiro S,Ruan S,Furukawa K.et al.Genetic and enzymatic basis for the differential expression of GM2 and GD2 gangliosides in human cancer cell lines.Cancer Res,1993,53(22):5395
-
6[6]FurukawaK,Soejima H,Niikawa N,et al.Genomlc organization and chromosomal assignment of the human betal,4-N-acetylgalactos-aminyltransferase gene.Identification of multiple transcription units.J Biol Chem,1996,271(34):20836
-
7[7]Nagata Y,Yamashiro S,Yodoi J,et al.Expression cloning of beta 1,4 N-acetylgalactosaminyltransferase cDNAs that determine the expression of GM2 and GD2 gangli-osides.J Biol Chem,1992,267(17):12082
-
8[8]Yamashiro S,Haraguchi M,Furukawa K,et al.Substrate specificity of beta,4-N-acetylgalactosaminyhransferase in vitro and in cDNA-transfected cells.GM2/GD2 synthase efficiently generates asialo-GM2 in certain cells.J Biol Chem,1995,270(11):6149
-
9[9]Haraguehi M,Yamashire S,Furukawa K,et al.The effects of the site-directed removal of N-glycosyrlation sites from beta-1,4-N-acetylgalactosaminyltransferase on its function.Biochem J,1995,312(Pt 1):273
-
10[10]Ruan S,Raj BK,Lloyd KO.Relationship of glyeesyltransferases and mRNA levels to ganglioside expression in neuroblastoma and melanoma cells.J Neurochem,1999,72(2):514
-
1佘明金,秦凤展,吴穷,郑荣生.乳腺癌患者骨髓GalNAcT mRNA的检测及其临床意义[J].临床肿瘤学杂志,2005,10(4):370-373. 被引量：1
-
2佘明金,秦凤展,吴穷,郑荣生,汪子书.GalNAcT和CK19mRNA表达与乳腺癌骨髓微转移的相关性[J].蚌埠医学院学报,2005,30(6):490-492. 被引量：3
-
3乌肖林,耿敬姝.HMGA2、Smad4在胃腺癌组织中的表达及其与上皮间质转化的相关性[J].实用肿瘤学杂志,2013,27(1):26-30. 被引量：1
-
4张吉旺,彭晓.P16抑癌基因与造血系统恶性肿瘤[J].国外医学（输血及血液学分册）,1996,19(2):96-98.
-
5孟冬娅,薛文成,胡晓芳,胡华,王祎楠,罗军.结直肠癌中血管内皮生长因子与p53表达关系的比较研究[J].沈阳部队医药,2001,14(6):504-505.
-
6孔宪国,王忠.抑癌基因WT_1研究状况[J].国外医学（泌尿系统分册）,1997,17(4):162-165.
-
7许树旭,梁化歧.多发性骨髓瘤患者脑脊液中肿瘤坏死因子-α和白细胞介素-2受体的测定及其意义[J].综合临床医学,1998,14(2):187-187.
-
8周振英,吴晓柳,朱月清,沈宗丽,王亚平.肿瘤化疗对恶性肿瘤患者外周血细胞IL-2R表达的影响[J].肿瘤研究与临床,2001,13(1):28-30.
-
9杨彩虹,曾恒,陈安民.骨肿瘤动物模型研究的进展[J].中华实验外科杂志,2000,17(2):180-181. 被引量：3
-
10孙俊,徐达.膀胱癌动物模型的研究进展[J].中华实验外科杂志,2009(5):679-680. 被引量：4
