下呼吸道感染患者革兰阴性杆菌耐药性分析

Drug resistance anaiysis of gram-negative bacillus with lower respiratory tract infection

目的:分析我院下呼吸道感染患者的革兰阴性杆菌耐药情况;探讨对耐药菌感染的治疗方案。方法:用K-B法测定118株革兰阴性杆菌对14种抗菌药物的耐药率。结果:最常见的革兰阴性杆菌为铜绿假单胞菌,肺炎克雷伯菌,鲍氏不动杆菌,大肠埃希菌等;它们对14种抗菌药物有程度不同的耐药,产超广谱β-内酰胺酶(ESBLs)菌株的耐药性明显增高。结论:革兰阴性杆菌是下呼吸道感染的主要致病菌,监测革兰阴性杆菌耐药性对于临床合理使用抗菌药物十分重要;亚胺培南β-内酰胺类抗菌药物与β-内酰胺酶抑制剂复合制剂可作为ESBLs菌感染的选用药物,亚胺培南可作为首选药物。

Objective： To study the antimicrobial resistance of gram-negative bacilli isolated and its drug-resistant tendercy in patients with lower respiratory tract.Methods： The resistance rates of 118 cultures of gram-negative bacilli were determined by K-B method.Results： Pseudomonas aeruginosa,Klebsiella pneumoniae,Acinetobactor baumannii,Escherichia coli were the main pathogens.They were resistant to 14 kinds of antimicrobials.The resistance of ESBLs-producing strains increased prominently. Conclusion： Gram-negative bacilli are main pathogens of lower respiratory tract. It is important to investigate the information of gram-negative bacilli and to monitor their drug resistance;the first choice is imipenem.