抗生素相关性肠炎48例临床分析

Clinical Analysis on 48 Cases of Antibiotic-associated Diarrhea Patients

目的探讨抗生素相关性肠炎(AAC)的临床特点及防治要点。方法对我院近3年内发生的48例AAC患者的临床资料进行回顾性分析。结果抗生素相关性肠炎可发生于抗生素治疗期间或停用抗生素后;48例均行粪便培养,其中13例有病原菌存在,分别为10例难辨梭状杆菌,3例金黄色葡萄球菌,余35例培养阴性;口服甲硝唑或去甲万古霉素治疗有效;46例痊愈出院,2例因原发疾病加重而死亡。结论因对抗生素应用随意等原因,临床容易出现AAC。治疗方面应停用原用抗生素,应用甲硝唑或去甲万古霉素口服治疗,同时注意综合治疗。

Objective To approach the clinical features,reasons and prevention about antibiotic-associated diarrhea. Methods Following the diagnostic criteria of antibiotic-associated diarrhea,the symptoms and signs of 48 cases with antibiotic-associated diarrhea patients were analyzed and recent literatrues were reviewed. Results 40 eases treated with combined therapy were cured and 2 cases died of worsen of original disease. Conclusion Antibiotic-associated diarrhea is a common gastrointestinal complication in patients treated with antibiotic. It can be cured by combined therapy.