摘要
MicroRNA(miRNA)是一类内源性非编码的小RNA,广泛存在于动物、植物和病毒中.通过与目标mRNA互补配对,调控靶基因的表达或翻译,在生物体的发育、增殖、分化和凋亡等方面发挥重要的生理作用.最近研究表明miRNA与肿瘤发生存在密切关系.利用实验生物学及生物信息学方法对与肿瘤相关的miRNA进行研究是当前研究的热点.其中,在肝癌中目前已发现若干miRNA如miRNA-122、-21、-195、-18、-199等的异常表达与之有关.而在乙型肝炎病毒(HBV)感染相关疾病中的miRNA表达的研究尚不多见.本文就MicroRNA与肝癌发生发展之间的关系作一综述.
MicroRNA is a kind of endogenous noncoding small RNA,is universally present in animals,plants and viruses and plays an important role in the development,proliferation, differentiation and apoptosis of organisms through complementary pairing with target mRNA,which can regulate its expression or translation.Recent studies indicate that miRNA is closely associated with tumors.Study on tumor-associated miRNA using techniques of experimental biology and bioinformatics is currently a hot subject of research.Recent studies on hepatocellular carcinoma（HCC） have shown that HCC is correlated with abnormal expression of several miRNAs,such as miRNA-122,-21,-195,-18,-199a.However,few studies on miRNA expression in HBV-infected diseases are available.This paper reviews researches on the association of microRNA with the development of liver cancer.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第6期645-652,共8页
World Chinese Journal of Digestology
基金
国家自然科学基金
N0.30672067~~
