阿托伐他汀钙对动脉粥样硬化患者血浆hs-CRP、NO水平的影响

Intervention of Atorvastatin Calcium on Levels of NO and hs-CRP of Plasma of Patient with Acute Coronary Syndrome

目的研究阿托伐他汀钙对动脉粥样硬化(AS)患者血浆高敏C-反应蛋白(hs-CRP)和一氧化氮(NO)的影响。方法选择40例正常人作为对照组,40例动脉粥样硬化患者作为试验组,对动脉粥样硬化患者给予阿托伐他汀钙1个月干预治疗,测定治疗前后hs-CRP和NO水平,并与正常对照组比较。结果动脉粥样硬化组治疗前血浆hs-CRP明显(P<0.01)高于正常对照组,NO明显(P<0.01)低于正常对照组;给予阿托伐他汀钙治疗后血浆hs-CRP降低(P<0.05);血浆NO升高(P<0.05)。结论阿托伐他汀钙对动脉粥样硬化患者具有独立于降脂作用之外的抗炎作用。

Objective To investigate the effects of atorvastatin calcium on hs - CRP and NO of patients with acute coronary syndrome. Methods Experimental set with 40 patients with acute coronary were treated for one month under the intervention of atorvastatin calcium. Measured the level of hs- CRP and NO before and after treatment, and compared with the comparative set with 40 normal people. Results Hs - CRP of plasma of experimental set was stronger than that of comparative set （P 〈 0. 01 ） before treatment, while NO of experimental set was lower than that of comparative set （P 〈 0.01） . Hs-CRP of plasma lowered （P 〈0.05）and NO grew （P 〈0.05） after treatment with atorvastatin calcium. Conclusion Except lowering serum, atorvastatin calcium has the action of anti -inflammation to patient with acute coronary syndrome.