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替比夫定可作为慢性乙型肝炎患者一线治疗 被引量:12

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摘要 替比夫定具有抗HBV特异性,抑制病毒能力强,病毒耐药发生率低,HBeAg血清转换率高,可预测临床疗效,安全性良好,使用方便等特点,可以作为慢乙肝患者抗病毒治疗的一线选择。
出处 《哈尔滨医药》 2008年第2期18-19,共2页 Harbin Medical Journal
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参考文献9

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  • 2姚光弼.替比夫定治疗慢性乙型肝炎的应用[J].肝脏,2007,12(5):434-436. 被引量:25
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二级参考文献18

  • 1贾继东,侯金林,尹有宽,徐道振,谭德明,牛俊奇,周霞秋,王宇明,朱理珉,贺永文,任红,万谟彬,陈成伟,巫善明,陈亚岗,许家璋,王勤环,魏来,马红.替比夫定或拉米夫定抗乙型肝炎病毒的疗效预测探讨[J].中华肝脏病杂志,2007,15(5):342-345. 被引量:141
  • 2Bryant ML,Bridges EG,Placidi L,et al.Amiviral L-nucleosides specific for hepatitis B virus infection.Antimicrob Agents Chemother,2001,45:229-235.
  • 3Standring DN,Bridges ED,Placidi L,et al.Antiviral β-L-nucleosides specific for hepatitis B virus infection.Antiviral Chemist Chemother,2001,12:119-129.
  • 4Zhou XJ,Lim SG,Lloyd DM,et al.Pharmacokinetics of telbivudine following oral administration of escalating single and multiple doses in patients with chronic hepatitis B virus infection:pharmacodynamic implications.Antimicrob Agents Chemother,2006,50:874-879.
  • 5Zhou XJ,Lloyd DM,Chao GC,et al.Absence of food effect on the pharmacokinetics of telbivudine following oral administration in healthy subjects.J Clin Pharmacol,2006,46:275-281.
  • 6Lai CL,Lim SG,Brown NA,et al.A dose finding study of once-daily oral telbivudine in HBeAg-positive patients with chronic hepatitis B virus infection.Hepatology,2004,40:719-726.
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  • 8Lai CL,Gane E,Liaw YF,et al.Telbivudine (LdT) vs.lamivudine for chronic hepatitis B:first-year results from the international phase Ⅲ globe trial.Hepatology,2005,42:748A.
  • 9Lai CL,Gane E,Hsu CW,et al.Two-year results from the GLOBE trial in patients with hepatitis B:greater clinical and antiviral efficacy for telbivudine (LdT) vs Lamivudine.Hepatology,2006,44:222A.Abstact 91.
  • 10Poynard T,Chutaputti A,Hwang S G,et al.Sustained off-treatment HBeAg response in telbivudine and lamivudine treated HBeAg-positive patients from the GLOBE study.J Hepatol,2006,46:S27.Abstract 58.

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