摘要
目的检测系统性红斑狼疮(SLE)患者血浆中骨桥蛋白(OPN)的水平,分析其与SLE活动性及脏器损害间的关系。方法选择68例SLE患者和36名健康体检者,采用酶联免疫吸附试验(ELISA)检测其血浆中的OPN水平。记录采血时患者的系统性红斑狼疮疾病活动指数(SLEDAI)、实验室指标等。结果SLE患者OPN血浆水平明显高于正常对照组[(4.5±2.0)ng/ml与(1.6±0.7)ng/ml,P〈0.01]。SLE疾病活动组高于非活动组[(5.3±2.0)ng/ml与(3.4±1.3)ng/ml,P〈0.01];SLE患者伴有肾脏损害组高于无肾脏损害组[(5.8±2.1)ng/ml与(3.5±1.3)ng/ml,P〈0.01],有肺间质病变、胃肠道病变和心包炎的高于无脏器损害[(4.8±1.2)、(6.3±1.4)、(5.4±2.6)ng/ml与(3.5±1.3)ng/ml,P〈0.05],抗心磷脂抗体阳性患者OPN水平高于抗心磷脂抗体阴性患者[(5.3±2.4)ng/ml与(4.2±1.7)ng/ml,P〈0.05]。OPN血浆水平与SLEDAI呈正相关(r=0.523,P〈0.01),与尿蛋白定量(24h)呈正相关(r=0.403,P=0.001),与补体c3呈负相关(r=-0.398,P=0.001),与红细胞沉降率(ESR)、抗dsDNA抗体、抗Sm抗体、IgG、IgA、IgM、球蛋白及关节炎等无相关性(P〉0.05)。结论OPN可能参与SLE的发病,临床上可作为疾病活动及脏器损伤的观察指标。
Objective To detect the plasma level of osteopontin (OPN) in systemic lupus erythematosus (SLE) patients, and its correlation with disease activity as well as organ damage was analyzed. Methods The plasma level of osteopontin was measured by enzyme-linked immunosorbent assay in 68 SLE patients and 36 healthy controls. Results The plasma level of OPN was significantly higher in SLE patients than in healthy control group (P〈0.01). In SLE patients, the plasma OPN level was significantly higher in patients with renal damage than in patients without renal damage (P〈0.01). Patients with lung interstitial disease and gastrointestinal tract involvement, their plasma level of OPN was significantly higher than those of patients with inactive lupus (P〈0.01). The plasma level of OPN correlated positively and significantly with SLEDAI score (r=0.523, P〈0.001 ) and 24-hour urine protein excretion (r=0.403, P=0.001 ), but negatively correlated with serum C3 level (r=-0.398, P=0.001 ). There was no correlation between the plasma level of OPN and anti-dsDNA antibody, Sm antibody, erythrocyte sedimentation rate, serum IgG, IgA, lgM levels (P〉 0.05). Conclusion OPN may be involved in the pathogenesis of SLE, and may be a potential marker for disease activity and organ damage.
出处
《中华风湿病学杂志》
CAS
CSCD
2008年第4期242-244,共3页
Chinese Journal of Rheumatology
基金
安徽省卫生厅重点学科专项基金资助项目(05A014)
关键词
红斑狼疮
系统性
骨桥蛋白
血浆
Lupus erythematosus, systemic
Osteopontin
Plasma