脱亚胺基重组鼠聚微丝蛋白抗体在类风湿关节炎活动性评价中的意义

The value of anti-deiminated recombinant rat filaggrin antibody in predicting disease activity of rheumatoid arthritis

目的探讨脱亚胺基重组鼠聚微丝蛋白抗体（ArFA）在类风湿关节炎（RA）病情活动性判断中的意义。方法采用酶联免疫吸附试验（ELISA）分别测定61例活动性RA患者和48例非活动性RA患者血清中ArFA，并检测红细胞沉降率（ESR）、类风湿因子（RF）、C反应蛋白（CRP），记录关节压痛数、肿胀数、晨僵时间等RA病情活动性评价指标。同时比较20例RA患者治疗前后ArFA的水平变化。结果RA活动组的ArFA抗体水平较非活动组高[（130±35）U／L与（66±25）U／L，P=0．004]，治疗后ArFA水平较治疗前有明显下降（79．8U／ml与118．2U／ml，P=0．000）。结论ArFA可以反映RA病情的活动性，可作为RA临床活动评价指标之一。

Objective To investigate the value of deiminated recombinant rat filaggrin antibodies （ArFA） in predicting the activity of rheumatoid arthritis （RA）. Methods ArFA was detected with enzymelinked immunosorbent assay （ELISA） in 61 patients with active RA and 48 patients with inactive RA. The ESR, CRP, RF were measured, while tender joint count, swollen joint count and patient＇s general assessment were recorded. The level of ArFA in 20 RA patients was measured before and after treatment. Results The level of ArFA in patients with active RA was higher compared with patients with inactive RA [ （130±35） U/L vs （66±25） U/L, P=0.004 ], the level of ArFA after treatment was reduced （79.8 U/ml vs 118.2 U/ml,P= 0.000）. Conclusion The level of ArFA can predict disease activity of RA.