血清胆碱酯酶和总胆汁酸与慢性乙型肝炎患者肝脏病理损害的关系探讨

Relationship of serum cholinesterase and total bile acid levels with liver injuries in patients with chronic hepatitis B

目的探讨血清胆碱酯酶(CHE)、总胆汁酸(TBA)与慢性乙型肝炎肝脏病理损害的关系。方法检测303例经肝穿刺活检病理证实的慢性乙型肝炎患者血清CHE和TBA,并对其与肝活检组织病理炎症分级和纤维化分期进行相关性分析。结果随着肝脏病理炎症分级和纤维化分期的加重,血清CHE逐渐下降,而血清TBA逐渐升高。血清CHE与肝脏病理分级和分期呈显著负相关(P<0.01),血清TBA与肝脏病理分级和分期呈显著正相关(P<0.01)。结论临床上联合测定血清CHE和TBA可在一定程度上反映慢性乙型肝炎肝组织病理损伤的程度。

Objective To study the relationship of serum cholinesterase（CHE） and total bile acid（TBA） levels with liver injuries in patients with chronic hepatitis B. Methods Serum levels of CHE and TBAwere determined in 303 patients with biopsy-proven chronic hepatitis B. The relationship between the serum components and the grade of inflammation and fibrosis staging in hepatic tissues was analyzed. Results Serum CHE was gradually decreased but serum TBA elevated as the degree of hepatic inflammatory and fibrosis increased. There was an significantly negative correlations between serum CHE and the grade of inflammation and fibrosis staging in hepatic tissues （P〈0.01）. There was an positive correlations between serum TBA and the grade of inflammation and fibrosis staging in hepatic tissues （P〈0.01）. Conclusions Combined determination of serum levels of CHE and TBA might reflect the degree of hepatic inflammation and fibrosis in patients with chronic hepatitis B.