摘要
在过量的4-二甲氨基吡啶存在下,丙炔酸甲酯选择性地保护表儿茶素B环的邻二羟基得新化合物1;以三乙胺为催化剂,苄氧羰基氯选择性地保护儿茶素中A环的间二羟基得化合物2。1和2的结构经1H NMR,13C NMR和MS表征。并探讨了对儿茶素B环邻二羟基的保护。
orth-Dihydroxyl groups on B ring of epicatechin were protected selectly to obtain novel compound 1 with methyl propynoate in the presence of excess 4-dimethylaminopyridine. meta-Dihydroxyl groups on A ring of catechin were protected seleetly to obtain compound 2 with benzyl chloroformate using triethylamine as a catalyst. The structures of 1 and 2 were confirmed by ^1H NMR, ^13C NMR and MS. Protection of orth-dihydroxyl groups on B ring of catechin was also investigated.
出处
《合成化学》
CAS
CSCD
2008年第2期133-135,157,共4页
Chinese Journal of Synthetic Chemistry
关键词
表儿茶素
儿茶素
多酚化合物
羟基保护
epicatechin
catechin
polyphenolic compound
protection of hydroxyl group