β-(3，4-二羟基苯基)-α-羟基-N-[(R)-3-苯基-1-乙氧酰基丙基]丙酰胺的合成

Synthesis of β-(3,4-Dihydroxyphenyl)-α-hydrox-N-[(R)-(3-phenyl-1-ethyloxyformyl)propyl]propanamide

以3,4-二羟基苯甲醛为原料,经开环、Knoevenagel缩合、水解和Clemmensen还原反应合成了丹参素(5);5与(R)-2-胺基-4-苯基丁酸乙酯在DCC/DMAP作用下,脱去一分子水合成了β-(3,4-二羟基苯基)-α-羟基-N-[(R)-3-苯基-1-乙氧酰基丙基]丙酰胺(8)。8的结构经1HNMR,IR和MS表征。

Banshensu （5） was obtained from 3,4-dihydroxybenzaldehyde by the reactions of ring- opening reaction, Knoevenagel condensation, hydrolization and Clemmensen reduction. β-（3,4-dihydroxyphenyl） -α-hydrox-N- [ （R） - （3-phenyl-1 -ethyloxyformyl） propyl ] propanamide （8） was synthe- sized by the reaction of 5 with （R）-2-amino-4-phenyl ethyl butyrate in DCC/DMAP. The structure of 8 was confirmed by ^1H NMR, IR and MS.