无偿献血者不同人群抗-HCV流行情况调查研究

Investigation and study on prevalence of anti-HCV among different voluntary blood donors

目的：了解济南市无偿献血者抗-HCV流行情况，确定低危献血群体，为安全输血提供保障。方法：选择2004-2006年济南市无偿献血者163854人，应用ELISA法检测其抗-HCV。统计学方法采用X^2检验。结果：抗-HCV阳性率0．52％（847／163854），各年阳性率分别为0．75％、0．43％、0．36％，（X^2=94．08，P〈0．01）。其中2006年男性阳性率为0．37％、女性阳性率为0．35％，差异无统计学意义（X^2=0．17，P〉0．05）；初次献血者阳性率为0．53％、多次献血者阳性率为0．27％，差异有统计学意义（X^2=23．45，P〈0．01）；18～30岁、31～40岁、41～55岁不同年龄段阳性率分别为0．37％、0．39％、0．23％，差异无统计学意义（X^2=2．93，P〉0．05）；不同职业间（学生和现役军人、其他职业者）阳性率分别为0．32％、0．43％，差异有统计学意义（X^2=3．85，P〈0．05）。结论：多次献血者或学生和现役军人是安全输血的低危人群，应作为主要选择对象。

Objective：To investigate the prevalence of anti-HCV in voluntary blood donors in Jinan City in order to determine the low dangerous donor population and ensure safe transfusion. Method： 163854 voluntary blood donors in Jinan City were selected and anti-HCV was detected by ELISA during 2004-2006. TheX^2 test was used to statistic analysis. Result： The positive rate of anti-HCV was 0.52% （847/163854）. The positive rates of anti-HCV in 2004,2005 and 2006 were0.75%,0.43% and 0.36%, respectively. There was significant differences（x^2 =94.08, P〈0.01）. The positive rates of anti-HCV in male and female voluntary blood donors were 0.37% and 0.35%, respectively, There was no significant difference（x^2 =0. 17, P〉0.05）. The positive rates of anti-HCV in first time donors and repeated donors were 0.53% and 0.27%, respectively. There was a significant difference （X^2 =23.45, P〈0.01）. The positive rates of anti-HCV in 18-30 years old, 31-40 years old and 41-55 years old were 0.37%, 0.39 % and 0.23%, respectively. There was no significant difference（X^2=2.93, P〉0.05）. The positive rate of anti-HCV of students and active duty personnels was 0.32%,others was 0. 43%. There was a significant difference（X^2=3.85, P〈0.05）. Conclusion：The repeated blood donors, students and active duty personnels were ideal blood donor population.They should be selected as the major objects for safe transfusion.