摘要
目的探讨ER、PR、Ki67、以及P53在乳腺癌中表达的相关关系及其临床意义。方法对126例原发性乳腺癌患者进行手术治疗,术后常规检测腋淋巴结状况,并采用免疫组织化学方法半定量测定乳腺癌ER、PR、Ki67和P53的表达,将腋淋巴结状况与以上分子表达进行对比分析。结果腋窝淋巴转移阳性率为41.6%,ER、PR、Ki67和P53表达阳性率分别为62.8%、75.4%、72.2%和54.8%,ER和PR表达呈显著正相关,P53与Ki67表达呈正相关,淋巴结转移与ER、PR、Ki67、P53表达无显著相关(P>0.05)。结论乳腺癌淋巴结转移状况与ER、PR、Ki67、P53表达是相互独立又相互补充的影响预后的因素。
Objective To investigate the correlations between lymph node status of patients with breast cancer and the expression of ER, PR, Ki67 and P53 in cancer tissue, and their clinical significance. Methods A hundred and twenty-six patients with primary breast cancer were treated surgically. Lymph node status and expressions of ER, PR, Ki67 and P53 in cancer tissue were assessed pathologically and by immunohistochernistry after operation, and the correlations between the lymph node status and the expressions of ER,PR,Ki67 and P53 was 62.8% ,75.4% ,72.2% and 54.8% analyzed. Results The positive rate of lymph node metastasis was 41.6% The positive rate of ER,PR,Ki67 and p53 was 62.8% ,75.4% ,72.2% and 54.8% respectively. The expression of ER had a positive correlation with that of PR and the expression of Ki67 had a positive correlation with that of P53. The lymph node status did not relate to the expressions of ER, PR, Ki67 and P53 （P 〉 0.05）. Conclusion Both the lymph node status of patients with breast cancer and the expressions of ER,PR,Ki67 and P53 in cancer tissue are independent and complementary of estimating the prognosis of the disease.
