期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

PPAR及其激动剂与脂肪酸代谢及胰岛素抵抗 被引量：6

Role of peroxisome proliferator-activated receptors and their agonists in fatty acid metabolism and insulin resistance
下载PDF
导出
摘要 过氧化物酶体增殖物激活受体(PPAR)在脂肪细胞分化、脂肪酸代谢中起重要作用,PPAR及其所调控基因的激活可促进脂肪细胞分化、减少脂质产生、增加脂肪酸氧化,从而减少脂质的异位沉积,进一步改善损伤的胰岛素信号转导通路,逆转胰岛素抵抗。针对脂肪酸合成及氧化的关键调控点的药物可能是今后治疗胰岛素抵抗引发的一系列代谢异常的新的靶点。 The peroxisome proliferator-activated receptors （PPAR） play an important role in adipocyte differentiation and fatty acid metabolism, activation of PPAR may induce the differentiation of adipoeyte,influence the expression of genes involved in lipogenesis and fatty acid oxidation, eventually lessen ectopic fat accumulation and improve the impaired insulin signaling, so the medicine which targets to the control point of FFA metabolism would be hopeful in the treatment of a cluster of metabolic abnormalities resulted from insulin resistance.
作者 白秀平 李宏亮 杨文英
机构地区 卫生部中日友好医院内分泌科
出处 《国际药学研究杂志》 CAS 2008年第2期111-115,共5页 Journal of International Pharmaceutical Research
关键词 过氧化物酶体增殖物激活受体 脂肪酸代谢 胰岛素抵抗 peroxisome proliferator-activated receptors fatty acid metabolism insulin resistance
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献25

  • 1[1]Guerre-Mino M,Gervois P,Raspe E,et al.Peroxisome prolifera-tot-activated receptor α activators improve insulin sensitIVity and reduce adiposity[J].J Biol Chem,2000,275(22):16638-16642.
  • 2[2]Li P,Zhu Z,Lu Y,et aL.Metabolic and cellular plasticity in white adipose tissue Ⅱ:role of peroxisome proliferator-activated receptorα[J].AmJPhysiolEndocrinolMemb,2005,289(4):E617-E626.
  • 3[3]Baden G,Laakso M.Lipids and glucose in type 2 diabetes:what is the cause and effect?[J].Diabetes Care,2004,27(9):2253-2259.
  • 4[4]Ide T,Tsunoda M,Mochizuki T,et al.Enhancement of insulin signaling through inhibition of tissue lipid accumulation by activa-tion of peroxisome proliferator-activated receptor α in obese mice[J].Med Sci Monit,2004,10(10):BR388-BR395.
  • 5[5]Minnich A,Tian N,Byan L,et al.A potent PPARα agonist stimulates mitochondrial fatty acid β-oxidation in liver and skele-tal muscle[J].Am J Physiol Endocrinol Metab,2001,280(2):E270-E279.
  • 6[6]Guerre-Millo M,Rouanlt C,Poulain P,et al.PPAR-α-null mice are protected from high-fat diet-induced insulin resistance[J].Diabetes,2001,50(12):2809-2814.
  • 7[7]Buchanan J,Masumder PK,Hu P,et al.Reduced cardiac effi-ciency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity[J].Endocrinology,2005,146(12):5341-5349.
  • 8[8]He W,Barak Y,Hevener A,et al.Adipose-specific peroxiseme prelfferator-activated receptor γ knockout causes insulin resist-ance in fat and liver but not in muscle[J].Proc Natl Aead Sci USA,2003,100(26):15712-15717.
  • 9[9]Semple RK,Chatterjee VK,O'Rabilly S.PPARγ and human metabolic disease[J].J Clin Invest,2006,116(3):581-589.
  • 10[10]Cack TA,Houten SM,Auwerx J.Peroxisome preliferator-activa-ted receptor-γ:too much of a good thing causes harm[J].EMBO Rep,2004,5(2):142-147.

二级参考文献13

  • 1杨文英,邢小燕,林红,马晓华,胡英华,李光伟,潘孝仁.高甘油三酯血症是非胰岛素依赖型糖尿病发病的危险因素──432例非糖尿病人群六年前瞻性观察[J].中华内科杂志,1995,34(9):583-586. 被引量：143
  • 2Storlien LH, James DE, Burleigh KM, et al. Fat feeding causes widespread in vivo insulin resistance, decreased energy expenditure, and obesity in rats. Am J Physiol, 1986, 251(5 Pt 1):E576-E583.
  • 3McGarry JD. Banting lecture 2001:dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes,2002,51:7-18.
  • 4Lee Y,Hirose H, Ohneda M,et al. Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci U S A, 1994,91: 10878-10882.
  • 5Randle PJ,Garland PB,Hales CN, et al. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet, 1963,1: 785-789.
  • 6Boden G, Chen X, Ruiz J, et al. Mechanism of fatty acid-induced inhibition of glucose uptake. J Clin Invest, 1994, 93: 2438-2446.
  • 7Weyer C, Funahashi T, Tanaka S, et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and huperinsulinemia. J Clin Endocrinol Metab, 2001,86:1930-1935.
  • 8Maeda N, Shimomura I, Kishida K, et al. Diet-induced insulin resistance in mice lacking adiponetin/ACRP30. Nat Med, 2002, 8:731-737.
  • 9Yamauchi T, Kamon J, Waki H, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med, 2001, 7:941-946.
  • 10Combs TP, Berg AH, Obici S, et al. Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. J Clin Invest, 2001,108:1875-1881.

共引文献64

同被引文献98

引证文献6

二级引证文献55

国际药学研究杂志
2008年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部