转铁蛋白在蛋白多肽药物口服给药中的应用

Transferrin in peroral delivery of protein and peptide

转铁蛋白作为一种药物载体,在蛋白多肽药物的口服给药领域有着美好前景。以转铁蛋白作为药物载体,可以使蛋白肽类药物在肠道吸收;对转铁蛋白进行适当的修饰,可以提高其递送效率。本文概述了近年来转铁蛋白在蛋白多肽药物口服给药中的作用及有关转运机制的研究进展。

The utilization of transferrin as a carrier in peptide and protein peroral drug delivery is a promising approach. Using transferrin as a drug carrier can render the absorption of peptide and protein in gastrointestinal tract. Modified transferrin will increase its drug delivery efficiency. In this paper, the progress of transferrin applied in protein and peptide peroral delivery is reviewed, and the transportation mechanism of transferrin is also discussed.