氟哌啶醇治疗糖尿病性胃轻瘫临床疗效观察

Observation of clinical curative effect of Haloperidol in treatment of diabetic gastroparesis

目的探讨氟哌啶醇治疗糖尿病性胃轻瘫的疗效。方法应用氟哌啶醇治疗45例糖尿病性胃轻瘫患者,并与盐酸甲氧氯普胺组进行对照。观察药物的临床疗效、对血糖的影响和不良反应。结果氟哌啶醇对饱胀、早饱、恶心和(或)呕吐有效率100%,腹胀,餐后不适有效率分别为89.2%和81.2%,尤其是对缓解饱胀、早饱、腹胀、恶心/呕吐和餐后不适等糖尿病胃轻瘫症状明显优于对照组(P<0.05),并有助于血糖的控制,且不良反应轻微。结论氟哌啶醇是治疗糖尿病性胃轻瘫安全有效的药物,有推广应用价值。

[Objective] To explore the curative effect of Haloperidol in the treatment of diabetic gastroparesis. [Method] 82 patients suffered from diabetic gastroparesis were involved in the study. 45 patients were given Haloperidol in the treatment group and the other 37 patients were given Metoclopramide in the controlling group, so that to observe the clinical curative effect of the two medicines and their impact and untoward reaction to blood sugar. [Results] The effective power of haloperidol for relieving full distend, full early, nausea and（or） vomit was 100%, and for relieving abdominal distention, indisposition after meal were 89.2%,and 81.2% respecvively. The effective power of Haloperidol for relieving the symptom of diabetic gastroparesis ut supra obviously outstriped that of Metoclopramide （P 〈0.05）. Besides, Halopefidol was good for the control of blood sugar, which untoward reaction was slight. [ Conclusion] Haloperidol is an safe and effective medicine for the treatment of diabetic gastroparesis, which is worthy of expanding.