心脏原发性多发肿瘤临床与病理分析(附16例报告)

Clinical and pathological analysis of primary multiple cardiac tumors (report of 16 cases)

目的分析心脏原发性多发肿瘤的临床与病理特征。方法回顾性分析我院1981年1月至2007年12月经病理确诊的16例心脏原发性多发肿瘤患者的临床与病理资料,并进行电话随访。结果本组16例中,男8例,女8例;年龄1～64岁,平均(30.9±15.7)岁;病程1个月～15年,平均1.2年。15例行深低温体外循环下心脏直视手术摘除瘤体,其中3例行瓣膜置换;另1例行同种异体原位心脏移植。无围手术期死亡者,术后4例复发。超声心动图检查均示心脏占位病变,2例伴心包积液,7例漏诊。16例中黏液瘤9例,肉瘤2例,横纹肌瘤、浸润性脂肪瘤、淋巴管瘤、副神经节瘤、不典型纤维组织细胞瘤各1例。结论心脏原发性多发肿瘤以黏液瘤为主。手术难度大,术中要仔细探查,避免遗漏。术后复发率高,确诊后应及早手术。

Objective To analyze clinical and pathological feature of primary multiple cardiac tumors. Methods Sixteen cases of primary multiple cardiac tumors collected from Jan 1981 to Dec 2007 in our hospital were treated surgically. Their clinical and pathological records were reviewed and followed. Results Sixteen cases included 8 male and 8 female ranged from 1 to 64 years old with the avarage age of （30.9±15.7）years old, disease course from one month to 15 years. All cases were treated surgically. The cases included nine myxomas, two sarcomas, one rhabdomyoma, one infiltrating lipoma, one lymphangioma, one paraganglioma and one atypical fibrous histiocytoma. Four cases relapsed.Seven cases had missed diagnosis by preoperative echocardiography. Conclusions Myxoma is the main type of primary multiple cardiac tumors. The operation for primary multiple cardiac tumors is difficult. Probing tumors should be careful to avoid omission. The surgical treatment would be good as soon as possible for the high recurrence rate.