雌甾-卟啉仿酶模型化合物的合成、构型与反应性

Synthesis,Configuration and Properties of Estrogenic Steroidporphyrin Enzyme Model Compounds

１７β－雌二醇与氯乙酰氯反应所得产物２与卟啉１反应，合成了雌甾－双卟二聚体３及雌甾单卟啉４，引入金属后得到雌甾－卟啉钴仿酶模型化合物３ａ及４ａ。它们的结构与构型经ＵＶ－Ｖｉｓ，ＩＲ，＾１ＨＮＭＲ和元素分析确证，并考查了３ａ对氢醌氧化反应的催化性能。

The model compounds of estrogenic steroid - bisporphyrins (3a) and estrogenic steroid - monoporphyrin (4a) have been synthesized by the reaction of porphyrin 1 with acyl choride of estradiol 2 followed by inserting of metal ion. The structures and configurations of 3a,4a,and the corresponding precursors 3 and 4 were confirmed by UV - Vis, IR, 1H NMR spectra and elemental analysis. The catalytic property of 3a towards oxidation of p - benzenediol was investigated.