相同人群连续3年HPV感染状况分析

Analysis of HPV infection status in the same patient group for 3 consecutive years

目的:调查相同人群HPV连续3年的感染情况,了解深圳妇女HPV3年累计感染率、转阴率、3年持续感染率,为防治宫颈癌提供依据。方法:收集2004、2005、2006年连续3年均在我单位妇女体检中心妇检的固定人群,同时进行宫颈液基细胞学(LCT)和宫颈分泌物13种高危型人乳头瘤病毒检测,对其中LCT≥宫颈不典型鳞状上皮细胞(ASCUS)和/或人乳头瘤病毒(+)女性进行阴道镜检查及宫颈活体组织检查。结果:该固定人群2004、2005、20063年HPV阳性率分别为18·12%、17·49%、18·34%;3年该人群的累计感染率为29·49%;转阴率为<35岁为76·26%(151/198)、≥35岁为23·74%(47/198);持续感染率为56·18%(300/534)。结论:深圳地区HPV感染情况比宫颈癌高发区低,但感染状况不容乐观,年轻、性生活活跃者较易感染高危型HPV且易于清除;对HPV感染的忽视与过分恐惧都是不适宜的;目前最为理想、且能从根本上防范子宫颈癌的办法是采用疫苗进行预防。

Objective： To investigate the HPV infection status in the same patient group, understanding the accumulative frequency, the rate of regression and the rate of persistence of Shenzhen women in three consecutive years, in Order to providea basis for cervical cancer prevention. Methods： Data of a fixed group of patients tested simultaneously for liquid - based cytology （LCT） and 13 types high - risk HPV DNA in 2004, 2005 and 2006 were collected in our clinic. Colposcopy and biopsies were performed for those patients with ≥ AS- CUS in LCT and/or HPV （ ＋ ） testing. Results： The HPV positive rates of the same patient group in 2004, 2005 and 2006 were 18. 12%, 17.49% and 18.34% respectively. The 3 -year accumulative frequency of HPV infection was 29. 49%. The regression rate was 76. 26% （151/198） for women age 〈35; and 23.74% （47/198） for women age ≥35. The rate of persistent HPV infection was 56. 18% （300/ 534） . Conclusion： The rate of HPV infection in Shenzhen is lower compared with other regions of high incidence of cervical cancer, but the status is not optimistic. Women in young ages or with active sexual life are more likely to be infected with high - risk HPV, but much easier to be cleared of. Over - stressing and negligence of HPV infection are inappropriate. Till now, the most ideal method that can fundamentally prevent HPV infection is by prophylactic vaccination.