缬沙坦对冠状动脉支架术后C反应蛋白水平的影响

Effect of Valsartan on C-Reactive Protein Levels After Coronary Stenting

目的：探讨缬沙坦对冠状动脉支架术后C反应蛋白（CRP）水平的影响。方法：选取稳定性心绞痛及陈旧性心肌梗死行冠状动脉支架术患者,分为缬沙坦组（19例）及对照组（21例）,缬沙坦组术前1个月至术后1周均服用缬沙坦80～160 mg/d,观察支架术前、术后24 h、术后72 h、术后1周的CRP水平。结果：手术前两组CRP无明显差别,术后24 h及72 h两组CRP均明显升高（P〈0.001）,但缬沙坦组CRP水平明显低于对照组（P〈0.05）。术后1周两组CRP恢复正常,与术前比较均P〉0.05。结论：缬沙坦降低了冠状动脉支架术后CRP水平。

Objective：To investigate the effect of valsartan on C-reactive protein levels （CRP） after coronary stenting. Methods： 40 patients with stable angina or old myocardial infaetion were randomized to valsartan group （n= 19） and control group（n= 21）,underwent eornary artery stenting. The individuals in valsartan group were treated with valsartan 80-160 mg once or twice daily for one month before stenting and one week after stenting. Venous blood sampies were collected to determine CRP levels before intervention, serially at 24 hours, 72 hours, 7 days after the intervention. Results：Preprocedural CRP levels did not differ significantly in two groups. The levels of CRP at 24 hours and 72 hours after the intervention were significantly increased in both valsartan group and control group（P〈0. 001）,and the levels of CRP were normal at 7 days after the intervention . The values of CRP were significantly lower in valsartan group than in control group at 24 hours and 72 hours after the intervention（P〈0.05）. Conclusion：Valsartan suppresse the levels of CRP after coronary stenting.