血管内皮生长因子在鉴别早期异位妊娠诊断中的价值

Evaluation of vascular endothelial growth factor in early diagnosis of non-typical ectopic pregnancy

目的通过对154例可疑异位妊娠患者血清血管内皮生长因子（VEGF）的测定，确定诊断异位妊娠的临床最佳分界值。方法将符合纳入标准的154例异位妊娠患者，用酶联免疫吸附法检测血清VEGF浓度，根据检测结果建立受试者工作特性曲线（ROC曲线）。结果曲线下面积为0．95，说明VEGF对早期异位妊娠有较好的诊断价值。通过ROC曲线确定诊断早期异位妊娠的最佳临界值为200pg／ml。结论VEGF可作为异位妊娠早期诊断的辅助指标，以其临界值诊断有利于减少误诊率。

Objective To investigate the best dignostic cut-off point of non-typical ectopic pregnancy （EP） through the determination of vascular endothelial growth factor（ VEGF） in 154 cases of suspected ectopie pregnancy patients. Methods The serum level of VEGF in 154 cases with suspected EP was determined by means of immunossay technique,and the results were made into ROC-Curve. Results The acreage behind the curve was 0.95, illustrating that the VEGF can be as a better marker for early diagnosis of EP. The serum VEGF level of 200pg/ml was the cut-off point for early diagnosis of EP through ROC-Curve. Conclusion The serum VEGF can be considered as an early diagnostic marker of EP,which cut-off point is benifical to reducing misdiagnosis of EP.