胰腺癌组织中VEGF-D、MMP-2的表达及意义

Expression and significance of VEGF-D and MMP-2 in pancreatic carcinoma

目的探讨胰腺癌组织中血管生长因子-D（VEGF-D）和基质金属蛋白酶-2（MMP-2）的表达与肿瘤侵袭转移的关系。方法应用免疫组化SABC法检测VEGF-D和MMP-2在30例胰腺癌和6例正常胰腺组织中的表达。结果胰腺癌组织中VEGF-D和MMP-2的高表达率分别为60％（18／30）和66．7％（20／30），而正常胰腺组织中未检测到VEGF-D和MMP-2的表达。VEGF-D的高表达率与淋巴结转移密切相关（P〈0.05），MMP-2的高表达率与淋巴结转移和肿块浸润程度有关（P〈0.05）。二者在胰腺癌组织中的表达呈正相关（rs=0．54，P〈0．01）。结论胰腺癌中有VEGF-D和MMP-2的高表达，二者表达呈正相关，与胰腺癌的侵袭转移关系密切。

Objective To investigate the expression of VEGF-D and MMP-2 and explore their relationship with tumor invasion and local metastasis in pancreatic carcinoma. Methods The expression of VEGF-D and MMP-2 in 30 patients with pancreatic carcinomas and 6 cases with normal pancreatic tissues were detected by SABC immunohistochemical method. Results The positive rates of VEGF-D and MMP-2 proteins were 60% （18/30） and 66. 7% （20/30）respectively, no expression of VEGF-D and MMP-2 was detected in normal pancreatic tissues, The expression of VEGF-D was significantly correlated with lymph node metastasis （ P 〈0.05 ） , and the expression of MMP-2 was significantly correlated with lymph node metastasis and tumor local invasion（ P 〈0. 05 ）. The expression of VEGF-D protein was posi-tively correlated with MMP-2 protein （rs= 0.54, P 〈0.01）. Conclusions There is a significantly positive correlation between high expression of VEGF-D and MMP-2 proteins in pancreatic carcinoma, and they may contribute to the invasive properties of pancreatic cancer.