2001-2006年河北省急性弛缓性麻痹病例中非脊灰肠道病毒感染病例流行病学分析

Epidemiological Analysis of Acute Flaccid Paralysis Associated with Non-polio Enterovirus in Hebei Province From 2001 to 2006

目的了解河北省近几年非脊髓灰质炎(脊灰)肠道病毒(NPEV)病例流行病学特征,为有效控制NPEV感染提供有价值的基础资料。方法结合省脊灰实验室病原学监测结果,分析全省急性弛缓性麻痹(AFP)病例监测系统上报的个案调查表、随访表。结果2001-2006年AFP病例监测系统共报告病例2515例,其中2491例至少采集了1份粪便标本,从273例AFP病例中检出NPEV,平均分离率为11.0%。273例NPEV感染的AFP病例覆盖全省11个市,67.0%分布在该省中南部,有明显季节性高峰,5岁以下儿童占79.5%,男性高于女性,脊灰减毒活疫苗(OPV)全程免疫占89.0%,临床诊断为格林巴利(GBS)80例(29.3%);NPEV感染79例(28.9%)。结论从AFP病例中能检出一定量的NPEV,NPEV监测应逐渐整合到AFP病例监测系统中,加强NPEV感染导致儿童麻痹的控制工作。

Objective To understand epidemiological characteristics of non-polio enterovims （NPEV） in acute flaccid paralysis （AFP） cases in Hebei Province from 2001 to 2006 and to provide scientific evidences for controlling NPEV infection. Methods Combining with the detecting results of pathogen, AFP cases reported by AFP surveillance system of Hebei Province were analyzed. Results During 2001 to 2006, 2 515 AFP cases were reported by the AFP surveillance system and one stool sample at least were collected among 2 419 cases. A totall of 273 NPEV cases distributed in 11 cities of the province were isolated and the average isolation rate was 11.0%. 67.0% of NPEV cases came from middle and south area of Hebei Province and there was an obvious seasonal peak. There were 79.5% of NPEV cases occurred in children under 5 years old. The rate of male was higher than that of female. The rate of full- course immunization was 89.0%. The clinical diagnoses of Guillian Barre＇ syndrome（GBS） and NPEV infection were 29.3% （80 cases） and 28.9% （79 cases）, respectively. Conclusion NPEV surveillance should be integrated into AFP surveillance. The control of paralysis caused by NPEV should be strengthened.