高尿酸血症加快老年颈动脉斑块患者认知功能损害的发生

Hyperuricemia accelerate cognitive functional damage in older people with carotid plaque

目的研究重庆市老年颈动脉斑块患者并发高尿酸血症其认知功能损害的发生情况。方法随机抽取2005年10月～2007年10月，在本科住院并进行了螺旋cT脑血管成像（CTA）或数字减影CT全脑血管造影（DSA）检查，测定有颈动脉斑块的老年患者827例。采用问卷调查的方式了解既往病史，同时运用简易智能量表（MMSE）、物体记忆测验（FOM）及语言流畅性测验（RVR）对患者的认知功能进行评估。测评认知功能当天清晨测量血压，空腹抽血测定血糖、血尿酸、血脂。结果827例颈动脉斑块患者有高尿酸血症的154例（18．62％），平均MMSE评分为23．8±1．50。与无高尿酸血症组MMSE评分差异有统计学意义（P〈0．05）。有高尿酸血症FOM和RVR评分均明显降低，与无高尿酸血症组差异有统计学意义（P〈0．01）。结论高尿酸血症加快老年颈动脉斑块患者认识功能的损害。

Objective To explore the cognitive functional damage in older people with hyperuricemia and carotid Plaque. Methods Cluster random sampling methods were used in the investigation from oct 2005 to oct 2007. Total 827 participants with carotid plaque were selected after screened with the CTA or DSA. Mini-mental state examination （MMSE）,Fuld Object-Memory Evaluation（FOM） and Rapid Verbal Retrieve（RVR） were used to evaluate their cognitive functions. In the morning of the day to examine the cognitive function,all the objects were subjected to blood pressure measurement,fasting blood glucose ,Serum uric acid and serum lipid（cholesterol,triglyceride） were analyzed by automatic biochemical analyzer. Results Among 827 subjects,154 peoples （18.62%）with hyperuricemia. Compared with no hyperuricemia, the patients with hyperuricemia had lower MMSE scores（23.81± 1.50） ,furthermore ,the FOM and RVR scores were lower（P〈0.01） . Conclusion Hyperuricemi accelerate cognitive impairment for the patients with hyperuricemia.