回、汉族冠心病与血管紧张素转换酶基因多态性的相关性研究

The Study of ACE Gene polymorphisms in the the patient with coronary heart disease in Hui ethnic and Han ethnic in Ningxia

目的探讨血管紧张素转换酶基因插入/缺失多态性与宁夏回、汉族冠心病的相关性。方法运用聚合酶链反应技术对宁夏90例回族(冠心病组、对照组各45例)、80例汉族(冠心病组、对照组各40例)进行血管紧张素转换酶基因多态性检测,并进行分析比较。结果回族冠心病组DD基因型高于回族对照组(P<0.05),汉族冠心病组和对照组ACE基因型分布比较未出现统计学意义(P>0.05)。结论血管紧张素转换酶基因I/D多态性与回族冠心病存在一定关系。

Objective To explore the relationship between angiotensin-converting enzyme （ACE） gene polymorphism with the patients of coronary heart disease in Hui ethnic and Han ethnic in Ningxia. Methods 90 cases of Hui population were divided into control group （n =45） and CHD group （n =45）. 80 cases of Han population were divided into control group （n =40） and CHD group （n =40）. The polymorphysim of ACE I/D was examined by the means of polymerase chain reaction （PCR） and electrophoresis. Results DD genotype was more frequent in CHD group than in control group of Hui population （ P 〈 0.05 ）. There is no relationship between single ACE gene and CHD in Han ethnic. Conclusion DD genotype of ACE should be risk factor for CHD in Hui populations.