期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

CD_4^+、CD_(25)^+调节T细胞在宫颈癌患者外周血中的表达及临床意义 被引量：1

下载PDF
导出
摘要 目的观察宫颈癌患者外周血CD_4^+、CD_(25)^+调节T细胞表达情况。方法采用流式细胞术检测30例宫颈鳞癌、73例宫颈上皮瘤病变(CIN)及30例正常妇女外周血CD_4^+、CD_(25)^+调节T细胞表达百分率。结果宫颈鳞癌患者CD_4^+、CD_(25)^+调节T细胞表达率与CIN比较差异有显著性(P<0.01);CINⅢ型与CINⅠ型、CINⅡ型比较差异有显著性(P<0.01),CINⅠ型与CINⅡ型比较差异无显著(P>0.05)。结论宫颈癌患者外周血CD_4^+ CD_(25)^+调节T细胞数量表达率明显增高。CD_4^+、CD_(25)^+调节T细胞可能在宫颈癌患者免疫耐受中发挥重要作用。
作者 王鑫 高红 郑乐鹏
机构地区 宁波市大榭开发区院
出处 《现代实用医学》 2008年第1期37-37,45,共2页 Modern Practical Medicine
关键词 CD4^+阳性 CD25^+T淋巴细胞 宫颈肿瘤 癌 免疫
分类号 R730.3 [医药卫生—肿瘤] R737.33 [医药卫生—肿瘤]
  • 相关文献

参考文献3

  • 1郑怀美.妇产科学[M].3版.北京:人民卫生出版社,1991:272.
  • 2陈巧英,李大金.CD4^+CD25^+调节性T细胞的生物学特性及功能[J].中国免疫学杂志,2007,23(1):89-92. 被引量：25
  • 3Kingsley CL, Kkarim M,Bushell AR,et al. CD4^*. CD25^* regulatory T cell preterit graft rejection:CTA4 and IL-10 dependent immunoregulation of all respone [J].J Immunol, 2002,168(3): 1080-1086.

二级参考文献25

  • 1Maloy K J,Powrie F.Regulatory T cells in the control of immune pathology[J].Nat Immunol,2001,2(9):816-822.
  • 2Sakaguchi S,Sakaguchi N,Asano M et al.Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor a-chains(CD25).Breackdown of single mechanism of self-tolerance causes various autoimmune diseases[J].J Immunol,1995, 155(3):1151-1164.
  • 3Asano M,Toda M,Sakaguchi N et al.Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation[J].J Exp Med,1996, 184(2):387-396.
  • 4Shevach E M,McHugh R S,Piccirillo C A et al.Control of T cell activation by CD4^+CD25^+ suppressor T cells[J].Immunol Rev,2001, 182:58-67.
  • 5Sakaguchi S,kaguchi N,Shimizu J et al.Immunologic tolerance maintained by CD25^+CD4^+ regulatory T cells:their common role in controlling autoimmunity,tumor immunity,and transplantation tolerance[J].Immunol Rev,2001, 182(8):18-32.
  • 6Zelenika D,Adams E,Humm S et al.The role of CD4^+T-cell subsets in determining transplantation rejection or tolerance[J].Immunol Rev,2001,182(8):164-179.
  • 7Taylor P A,Lees C J,Blazar B R.The infusion of ex vivo activated and expanded CD4^+CD25^+ immune regulatory cells inhibits graft-ver-sus-host disease lethality[J].Blood,2002, 99(10):3493-3499.
  • 8Sutmuller R P,Van Duivenvoorde L M,Van Elsas A et al.Synergismof cy-totoxic T lymphoxyte-associated antigen 4 blockade and depleteon of CD25^+ regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte response[J].J Exp Med,2001, 194(6):823-832.
  • 9Aluvihare V R,Kallikourdis M,Betz A G et al.Regulatory T cells mediate maternal tolerance to the fetus[J].Nat Immunol,2004,5(3):266-271.
  • 10Sasaki Y,Sakai M,Miyazaki S et al.Decidual and peripheral blood CD4^+CD25^+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases[J].Mol Hum Reprod,2004, 10(5):347-353.

共引文献27

同被引文献8

  • 1章圣辉,韩义香,吴建波,胡晓霞.子宫颈癌患者外周血CD_4^+ CD_(25)^+CD_(127)^(lo/-)调节性T淋巴细胞的含量及肿瘤免疫水平检测[J].中华妇产科杂志,2007,42(6):419-420. 被引量：12
  • 2Kronenberg M, Rudensky A. Regulation of immunity by self-reactive T cells. Nature, 2005, 435: 598-604.
  • 3Moiling JW, De Gruijl TD, Glim J, et al. CD4+ CD25+ regulatory T - cell frequency correlates with persistence of human papillomavirus type 16 and T helper cell responses in patients with cervical intraepithelial neoplasia. Int J Cancer, 2007, 121: 1749- 1755.
  • 4Visser J, Nijman HW, Hoogenboom BN, et al. Frequencies and role of regulatory T cells in patients with (pre) malignant cervical neoplasia. Clin Exp Immunol, 2007, 150: 199 -209.
  • 5Tuve S, Chen BM, Liu Y, et al. Combination of tumor site-- located CTL-- associated antigen-- 4 blockade and sys- temic regulatory T - cell depletion induces tumor - destructive immune responses. Cancer Res, 2007, 67: 5929- 2939.
  • 6Beyer M, Schultze JL. Regulatory T cells., major players in the tumor microenvironment. Curr Pharm Des, 2009, 15: 1879 - 1892.
  • 7Vander Burg SH, Piersma SJ, De Jong A, et al. Association of cervical cancer with the presence of CD4+ regulatory T cells specific for human papillomavirus antigens. PNAS, 2007, 104: 12087- 12092.
  • 8Adurthi S, Krishna S, Mukherjee G, et al. Regulatory T cells in a spectrum of HPV--induced cervical lesions: cervicitis, cervical intraepithelial neoplasia and squamous cell car cinoma. Am J Reprod Immunol, 2008, 60: 55-65.

引证文献1

二级引证文献4

现代实用医学
2008年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部