基因芯片技术在食管癌研究中的应用进展

Advances in Application of Gene Chip Technique for Research of Esophageal Cancer

基因芯片技术是近几年发展起来的前沿生物技术,其高通量、快速、平行化采集生物信息的特点更是优于其他传统的技术方法,为研究肿瘤细胞生长各期与肿瘤生长相关基因的表达模式提供了强有力的工具。基因芯片技术不断应用于食管癌及其癌前疾病的研究中,为揭示食管癌发生发展的分子机制起到了巨大的促进作用,其特异的靶分子可以成为食管癌血清学诊断标记和基因治疗的靶标。现对基因芯片技术在食管癌研究中的应用进展作一简要概述。

Gene chip technique is the forefront biological technique developed recently for the study of gene expression. The differentially expressed genes in different specimens may be detected with parallel analysis by gene chips, which has greatly improved the traditional experiments in that only a single or several gene expression can be observed for each test, thereby speeding up the identification of differentially expressed genes and the construction of differential expression profiles. This technology has been applied for the study of esophageal cancer and precancerous lesions, and identified a number of candidate genes useful as biomarkers in cancer staging, prediction of recurrence, prognosis, and treatment option. Some of these target molecules have been used to develop new serum diagnostic markers and therapeutic targets against esophageal cancer.