鼻咽癌变过程中医体质证候调查

Clinical Survey on the Distribution of Constitutional Pattern among Cases with the Nasopharyngeal Tissue dDuring Carcinogenesis

目的:调查鼻咽癌癌变过程中医体质证候变化规律。方法:运用中医体质调查量表,在鼻咽癌高发区广东中山,对400例慢性鼻咽炎、80例鼻咽癌前病变、150例初诊鼻咽癌患者进行中医体质证候调查。调查结果采用SPSS(10.0)进行统计分析。结果:鼻咽炎患者体质多表现为正常质(66.8%)、气虚质(19.5%)和失调热质(13.5%);鼻咽癌癌前病变者多表现为正常质(54.1%)和气虚质(37.7%);鼻咽癌初诊患者多表现为正常质(60.7%)、失调热质(22.7%)、气虚质(16.0%)、失调湿质(16.0%)和复合质(13.3%)。3组患者体质证候积分比较显示,气虚分在鼻咽癌前病变患者中明显增多,失调偏寒分及偏瘀分在初诊鼻咽癌患者明显增多,P<0.05或P<0.01。结论:气虚为鼻咽癌变过程重要因素,鼻咽癌变后则可表现为热、湿、气虚、寒、瘀多类体质证候。

Objective ： To investigate the distribution of constitutional pattern among cases with the nasopharyngeal tissue during carcinogenesis. Methods ： Using the closed questionnaire of TCM, we surveyed the distribution of constitutional patterns among the members which included 400 cases with nasopharyngitis, 80 cases with nasopharyngeal precancerous lesion, 150 cases with nasopharyngeal carcinoma （NPC） which untreated. The investigate dates were analyzed by SPSS （10.0） software. Results： The predominant patterns of constitution among the nasopharyngitis were the normal pattern （ 66.8% ）, vacuous pattern（ 19.5% ） and the heat pattern（ 13.5% ）. The predominant patterns of constitution among the nasopharyngeal precancerous lesion were the normal pattern （54.1% ） and vacuous pattern （37.7%）. The predominant patterns of constitution among the NPC were the normal pattern （60.7%）, the heat pattern （22.7%）, vacuous pattern （ 16.0% ）, the dampness pattern（ 16.0% ） and complex pattern（ 13.3% ）. The vacuous pattern was obviously increased among the case with nasopharyngeal precancerous lesion, the cold pattern and stagnation pattern were obviously increased among the untreated NPC patients. Conclusion ： The vacuous play a very important role among cases with the nasopharyngeal tissue during carcinogenesis. The NPC patient have the character as the heat, the dampness, the vacuous, the cold and stagnation syndrome.