中药漱口方防治院内口腔真菌感染的临床观察

Observation the Clinical Efficacy by Using Traditional Chinese Medicine Grargle to Prevention and Treat Nosocomial Fungus Infection of Oral Cavity in High Risk Group

目的:观察中药漱口方预防及治疗院内口腔真菌感染的临床效果。方法:收集符合院内真菌感染高危人群的住院患者共70例,用药前常规检查咽拭子真菌培养,阴性者归入预防组,阳性者归入治疗组,两组均随机分组为中药组和对照组,预防对照组采用空白对照,治疗对照组采用口泰漱口液对照。1周后复查口咽拭真菌培养。结果:①中药漱口方对预防院内口腔真菌感染具有显著效果,其1周后发病率仅为12.50%,而未预防组1周后发病率为68.42%,两组比较具有显著统计学意义(P<0.01)。②中药漱口方对治疗院内口腔真菌感染具有一定的效果,其1周后转阴率为58.82%,略高于口泰治疗组的43.75%,但两组比较未见明显统计学意义(P>0.05)。结论:中药漱口方能够显著降低高危人群院内口腔真菌感染率,并具有一定的治疗作用。

Objective ：To observe the prevention and treatment efficacy by using traditional Chinese medicine gargle. Methods ： Collec 70 hospital patients which all accord with the high risk group of the nosocomial fungus infection. Check the fungus cultivation of oral cavity before using medicine. Collect the negative ones in the prevention group ,the positive ones in the treatment group. This two groups are all randomly divided into traditional Chinese medicine group and control group. The control group of prevention is blank ,and treatment adopts Kou Tai gargle. All the patients should be checked the fungus cultivation of oral cavity after on week. Results ：Traditional Chinese medicine gargle is effective in preventing nosocomial fungus infection of oral cavity. After one week＇s prevention, the incidence of traditional Chinese medicine group is only 12.50%. But the incidence of blank control group is 68.42%. There is obvious difference in the two groups （ P 〈0.01 ）. Traditional Chinese medicine gargle is to some extent effective in treating nosocomial fungus infection of oral cavity. There is 58.82% patients＇fungus cultivation of oral cavity turn to negative, which is a little higher than Kou Tai gargle group＇s 43.75%. But there is no difference between the two groups （ P 〉 0. 05）. Conclusion ：Using traditional Chinese medicine gargle has obvious prevention efficacy, which can reduce the infection rate of nosocomial fungus infection of oral cavity in high risk group,and has a distinctive curative effect.