子宫颈支原体感染与早产的关系

Relatoinship between the endocervical mycoplasma infection and spontaneous abortion due to preterm labor

目的探讨宫颈支原体感染与早产的关系及支原体药物敏感结果。方法收集60例正常足月妊娠妇女(正常组)与68例早产妇女(早产组)的宫颈分泌物进行解脲支原体和人型支原体的培养比较两组妇女支原体检出的阳性率,并对支原体培养阳性者进行罗红霉素、强力霉素、氧氟沙星药物敏感试验,观察支原体感染与早产之间的关系。结果(1)早产组解脲支原体阳性48例,阳性率70.59%,人型支原体20例,阳性率29.41%,两者均阳性15例,阳性率22.06%;正常组解脲支原体阳性28例,阳性率46.67%,人型支原体8例,阳性率13.33%,两者均阳性4例,阳性率6.67%。两组阳性率比较,差异有极显著性(P<0.01,P<0.05);(2)两组妇女中,支原体阳性患者的药物敏感率分别为罗红霉素93.49%,强力霉素62.35%,氧氟沙星37.63%。结论(1)宫颈支原体感染与早产有关,是导致早产的原因之一;(2)支原体药物敏感试验以罗红霉素为最敏感。

Objective：To study the relationship between endocervical mycoplasma infection and the spontaneous abortion due to the preterm labor and the drug sensitivity to mycoplasma.Methods：Endocervical swabs were taken from sixty normal pregnant women（normal group）and sixty-eight women with spontaneous abortion due to preterm labor.The swabs were used for ureaplasma urealyticum（UU）and mycoplasma hominis（MH） cultivation respectively.The isolation rates of the two groups were compared.Results：（1）In the preterm labor group,the positive rates of UU,MH and UU mixed with MH were 70.59%（48/68）,29.41%（20/68） and 22.06%（15/68）separately.In the normal female group,howere,the positive rates correspondingly were the UU 46.67%（28/60）,the MH 13.33%（8/60） and the UU mixed with MH 6.67%（4/60）.There had significant differences of the positive rates between the two groups（P〈0.01,P〈0.05）.（2）Drug sensitivity rates to mycoplasma were roxithromvcin 93.49%,doxycycline 62.35% and of loxacin 37.63%.Conclusion：（1）The endocervical mycoplasma infection could be one of the causes leading to the preterm labor.（2） Roxithromycin was the most sensitive drug tested to mycoplasma.