膀胱癌患者外周血淋巴细胞染色体畸变研究

Study on Chromosome Aberration of Lymphocytes in Peripheral Blood of Patients With Bladder Carcinoma

背景与目的:探讨膀胱癌患者外周血淋巴细胞染色体数目畸变与临床分期、病理分级及预后的关系。材料与方法:对30例膀胱癌患者行外周血淋巴细胞染色体数目畸变分析。结果:患者组中亚二倍体、超二倍体、多倍体的出现率明显增高,总畸变率明显高于正常对照组(P<0.05),且随着临床分期及病理分级的增加,染色体的二倍体率下降。结论:随着肿瘤恶性程度的增加,染色体变异范围扩大,多倍体的出现可能预示着肿瘤的恶性倾向和患者的预后不佳。

BACKGROUND AND AIM： To investigate the relationship between chromosome numerical aberration of lymphocytes in peripheral blood and clinical stage , pathological grading and prognosis in patients with bladder carcinoma. MATERIALS AND METHODS： Cytogenetic studies were taken on 30 bladder carcinoma by examining their chromosome numerical aberration of lymphocytes in peripheral blood. RESULTS： The frequencies of hypodiploid, hyperdiploid and polyloid were significantly increased.The general abnormality rate was significantly higher than the normal control group （P 〈 0. 05 ） . As the clinical staging and pathological grading became more advanced, the diploid rate was reduced. CONCLUSION： With higher malignant degree of bladder carcinoma, the range of chromosome numerical aberration increased. This indicated that the appearance of polyloidy was closely correlated with the malignant level of the carcinoma and unfavourable prognosis.