1Gardiner-Ganlen M, Frommer M. CpG islands in vertebrate genomes [J]. J Mol Biol, 1987, 196(2) :261- 82.
2Kobatake T, Yano M, Toyooka S, et al. Aberrant methylation of p57KIP2 gene in lung and breast cancers and malignant mesotheliomas [J]. Oncol Rep, 2004, 12(5):1087-1092.
3Mirza S, Sharma G, Prasad CP, et al. Promoter hypermethylation of TMS1, BRCA1, ERalpha and PRB in serum and tumor DNA of invasive ductal breast carcinoma patients[J]. Life Sci, 2007, 81(4): 280- 287.
4Esteller M . DNA methylation and cancer therapy:new developments and expectations[J]. Curr Opin Oncol,2005,17(1) :55 - 60.
5Dobrovic A, Simpfendorfer D. Methylation of the BRCA1 gene in sporadic breast cancer[J]. Cancer Res, 1997,57(16):3347-3350.
6Luczak MW, Jagodzinski PP. The role of DNA methylation in cancer development[J]. Folia Histochem Cytobiol,2006,44(3) : 143- 154.
7Dulaimi E, Hillinck J, Ibanez de Caceres I, et al. Tumor suppressor gene promoter hypermethylation in serum of breast cancer patients[J] . Clin Cancer Res, 2004, 10(18) :6189- 6193.
8Jandrig B, Seitz S, Hinzmann B, et al. ST18 is a breast cancer tumor suppressor gene at human chromosome 8q11.2[J] . Oncogene, 2004, 23(57) : 9295 - 9302.
9Lui EL, Loo WT, Zhu L, et al. DNA hypennethylation of TIMP3 gene in invasive breast ductal carcinoma[J] . Biomed Pharmacother, 2005,59(Suppl 2) : S363 - 365.
10Ehrlich M. DNA methylation in cancer: too much, but also too little [J]. Oncogene,2002,21(35) :5400- 5410.
4Hsu PI,Hsieh HL,Lee J,et al.Loss of RUNX3-expression correlates with differentiation,nodal metastasis,and poor prognosis of gastric cancer.Ann Surg Oncol,2009,16:1686-1694.
5Goelz SE,Hamilton SR,Vogelstein B.Purification of DNA from formaldehyde fixed and paraffin embedded human tissue.Biochem Biophys Res Commun,1985,130:118-126.
6Jones PA.DNA methylation and cancer.Cancer Res,1986,46:461-466.
7Herman JG,Baylin SB.Gene silencing in cancer in association with promoter hypermethylation.N Engl J Med,2003,349:2042-2054.
8Ito Y.RUNX genes in development and cancer:regulation of viral gene expression and the discovery of RUNX family genes.Adv Cancer Res,2008,99:33-76.
9Bae SC,Lee YH.Phosphorylation,acetylation and ubiquitination:the molecular basis of RUNX regulation.Gene,2006,366:58-66.
10Subramaniam MM,Chan JY,Yeoh KG,et al.Molecular pathology of RUNX3-in human carcinogenesis.Biochim Biophys Acta,2009,1796:315-331.
