中药复方病毒力克抗炎作用及其作用机理的研究

Study on the anti-inflammatory effect and mechanism of traditional Chinese compound recipe Bingdulike

研究兽用中药复方病毒力克的抗炎作用,并初步探讨其作用机理。采用小鼠耳肿胀模型、小鼠腹腔毛细血管通透性增高模型、小鼠足跖肿胀模型及小鼠纸片肉芽肿模型观察病毒力克的抗炎作用,同时测定小鼠角叉菜胶致足炎性渗出物中的MDA、HA、5-TH及血清中NO含量,研究病毒力克的抗炎机制。结果显示,病毒力克能显著抑制二甲苯所致小鼠耳肿胀,明显抑制醋酸引起的小鼠腹腔毛细血管通透性,减轻角叉菜胶致小鼠足跖肿胀度,并有抑制小鼠纸片肉芽肿的作用;病毒力克能明显降低角叉菜胶致足炎性渗出物中的MDA、HA、5-TH及血清中NO的含量。研究结果表明,病毒力克具有明显的抗炎作用,其抗炎机理与其抑制炎性介质MDA、histamin、5-TH及血清中NO的释放有关。

The anti-inflammatory effects of compound recipe Bingdulike and its possible mechanism was studied.The anti-inflammatory effects of Bingdulike were observed using mouse ear inflammation model induced by xylene,mouse peritoneal capillary permeability increase model induced by acetic acid,mouse paw edema model induced by carregenin and mouse granuloma model induced by paper.The anti-inflammatory mechanism of Bingdulike was studied by assessing the changes of the levels of the MDA,histamin and 5-TH in the inflammatory tissues and the NO in blood serum of mouse paw inflammation model induced by carregenin.The results showed that Bingdulike exhibited remarkable anti-inflammatory activity in xylene-induced mouse ear inflammation,acetic-acid-induced mouse peritoneal capillary permeability increasing,carrageenan-induced mouse paw edema and paper-induced mouse granuloma.Bingdulike reduced the levels of the MDA,histamin and 5-TH in the inflammatory tissues and the NO in blood serum of the mouse paw inflammation model induced by carregenin.These indicated that Bingdulike has an obvious anti-inflammatory effect.Its primary mechanism is related to the reduction of the levels of the MDA,histamin and 5-TH in the inflammatory tissues and the NO in blood serum.