妇炎康丸治疗慢性盆腔炎的实验研究

Experimental study of Fuyankang pill on chronic pelvic inflammatory disease

目的观察妇炎康丸对混合菌液致大鼠慢性盆腔炎的治疗作用。方法采用混合菌悬液注入大鼠子宫造成大鼠慢性盆腔炎,比较各组动物血液流变学指标,并对子宫标本作组织学镜检。结果造模25d,灌胃给药30d,模型组大鼠子宫粘膜上皮坏死变性,纤维结缔组织增生,形成粘连、包块为主。全血粘度、全血还原粘度、毛细管血浆粘度、红细胞聚集指数、红细胞刚性指数、血沉等血液流变学指标异常升高;妇炎康丸可不同程度改善子宫病理改变,并使多数血液流变学指标显著改善。结论采用混合菌悬液注入大鼠子宫可造成大鼠慢性盆腔炎模型。妇炎康丸对混合菌悬液致大鼠慢性盆腔炎有显著的治疗作用。

OBJECTIVE To study the effect of Fuyankang pill on hemorheology in rats with chronic pelvic inflammatory disease （CPID）, to approach the pathogeny of CPID and the action mechanism of Fuyankang pill.METHODS The models of CPID were made by injection of phenic alcohol into right uterus in rats,hemorheology index of each group were compared and uterus samples were tested under microscope in histolo- gy. RESULTS The viscosity of whole blood, plasma viscosity of capillary, erythrocyte aggregation, erythrocyte rigidity, and blood sedimentation rate were heightened abnormally in model rats, and with fibrous desmoplasia in histomorphology which form syncretio and lump mainly. Fuyankang relieved pathological changes in uterus.CONCLUSION Fuyankang CPID. pill reduced the viscosity of whole blood and pill can ameliorate hemorheology in rats with