期刊文献+

恶性肿瘤的放射治疗联合基因治疗研究进展

Advancement of researches on the malignant tumor radio-genetic therapy
原文传递
导出
摘要 放射治疗是恶性肿瘤治疗的常规手段之一,并早已用于临床。而基因治疗是一种新型的治疗方法,但由于肿瘤的形成是多因素、多基因参与的复杂过程,单纯基因治疗的效果并不理想。因此,放射治疗联合基因治疗是目前的研究热点,也将成为肿瘤治疗研究的重要方向之一。 Radiotherapy is one of the routine methods of malignant tumor treatment and used in clinical many years, while gene therapy is one of the new therapy. But the formation of tumor is the complicated process effected by many factors and many genes. The effect of polygene therapy is not ideal. Therefore, radio-genetic therapy is the hot spot of the present study and will become one of the important direction of cancer therapy.
作者 田玥 苏成海
出处 《国际放射医学核医学杂志》 2008年第1期43-46,共4页 International Journal of Radiation Medicine and Nuclear Medicine
关键词 放射疗法 基因疗法 肿瘤治疗方案 Radiotherapy Genetherapy Antineoplasticprotocols
  • 相关文献

参考文献24

  • 1Connell PP, Weichselbaum RR. Gene therapy: the challenges of translating laboratory research into clinical practice [J]. J Clin Oncol, 2003, 21(12): 2230-2231.
  • 2Weichselbaum RR, Hallahan DE, Beckett MA, et al. Gene therapy targeted by radiation preferentially radiosensitizes tumor cells [J]. Cancer nes, 1994, 54(16): 4266-4269.
  • 3Seethram S, Staba M J, Schumm IP, et al. Enhanced eradication of local and distant tumors by genetically produced interleukin-12 and radiation[J ]. Int J Oncol, 1999, 15(4) : 769-773.
  • 4Gridley DS, Baer JR, Cao JD, et al. TNF-alpha gene and proton radiotherapy in an orthotopic brain tumor model [J ]. Int J Oncol, 2002, 21(2): 251-259.
  • 5Sherman ML, Datta R, Hallahan DE. Ionizing radiation regulates expression of the c-jun protooncogene [J]. Natl Acad Sci USA, 1990, 87( 15 ) : 5663-5670.
  • 6Xian J, Yang H, Lin Y, et al. Combination nonviral murine interleukin 2 and interleukin 12 gene therapy and radiotherapy for head and neck squamous cell carcinoma [J]. Arch Otolaryngol Head Neck Surg, 2005, 131(12): 1079-1085.
  • 7Haupt S, Haupt Y. Importance of p53 for cancer onset and therapy [J ]. Anti Cancer Drugs, 2006, 17(7): 725-732.
  • 8Mimeault M, Batra SK. Recent advances on multiple tumorigenic cascades involved in prostatic cancer progression and targeting therapies[J ]. Carcinogenesis, 2006, 27(1): 1-22.
  • 9Baker SJ, Markowitz S, Fearon ER, et al. Suppression of human colorectal carcinoma cell growth by wild-type p53 [J]. Science, 1990, 249 (4971) : 912-915.
  • 10Guha A, Mukherjee J. Advances in the biology of astrocytomas [J ]. Curr Opin Neurol, 2004, 17(6): 655-662.

二级参考文献39

  • 1王全兴,曹雪涛,章卫平,周正芳,马施华,叶天星.瘤体内注射脂质体包裹的IL-2基因的抗肿瘤作用及其局部免疫机理分析[J].中国免疫学杂志,1995,11(5):290-293. 被引量:11
  • 2Weichselbaum RR, Hallahan DE, Sukhatme VP. Gene therapy targeting by ionizing radiation. Int J Radiat Oncol Bid Phys, 1992, 24:565-568.
  • 3Weichselbaum RR, Hallahan DE, Becktt MA, et al . Gene therapy by radiation preferentially radiosensitizes tumor cells. Cancer Res, 1994,54 :4266-4269.
  • 4Hailahan DE, Mancaeri HJ, Seug LP, et al . Spatial and temporal control of gene therapy. Nat Med, 1995, 1:786-789.
  • 5Staba M J, Maucer HI, Kufe DW, et al. Adenovioral TNF-alpha gene therapy and radiation damage tumor vasculature in a human malignant glioma xenograft. Gene Ther, 1998, 5:293-300.
  • 6Maucer HI, Hanna NN, Staba M J, et al. Radiation-inducible gene theraov. Life Sci. 1999. 322..225-228.
  • 7Nomura T, Yasuda K, Yamada T, et al. Gene expression and antitumor effects following direct interferon-ganuna gene transfer with naked plasmid DNA and DC-chol liposome complexes in mice. Gene Ther, 1999,6: 121-129.
  • 8Kim TS, Russel SJ, Colin MK, et al. Immunity to B16 melanoma in mice immunized with IL-2 secreting allogeneic meuse fibroblasts expressing melanoma-associated antigen. Int J Cancer, 1992, 51 : 283-286.
  • 9Zhang L, Yu D, Hu M, et al. Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression. Cancer Res, 2000,60:3655-3661.
  • 10Zhang EP, Lian PG, Cai KL,et al. Radiation therapy of nasopharyngeal carcinoma: prognostic factors based on a 10-year follow-up of 1302 patients. Int J Radiat Oncol Biol Phys, 1989,16:301-305.

共引文献34

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部