反复短暂性脑缺血发作对认知功能累积性损害的临床研究

Effect of Repeated Transient Ischemic Attacks on Cumulative Injury of Cognitive Function： A Clinical Study

目的：研究反复短暂性脑缺血发作（TIA）对认知功能的累积性损害。方法：采用事件相关电位、改良威斯康辛卡片分类测试、数字连线测试、数字广度测验、言语流畅性测验等评价42例反复TIA患者每次TIA发作后的认知功能状况，并对不同发作次数后的认知功能状况进行比较和分析。结果：不同发作次数后的认知功能状况、P300潜伏期和波幅、轻度认知障碍的检出率存在显著差异。随着发作次数增加，认知功能损害加重，轻度认知障碍的检出率逐渐增高。结论：反复TIA对认知功能可产生累积性损害效应，防治TIA有可能成为降低认知障碍患病率的重要途径。

Objective： To study the effect of repeated transient ischemic attacks （TIAS） on cumulative injury of cognitive function. Methods： The cognitive condition of 42 patients with repeated TIAS were assessed after each TIA using the event related potential, modified version of Wisconsin card sorting test, trail making test, digit span task, and verbal fluency test. The cognitive condition was compared and analyzed after different attack times. Results- There were significant differences among the cognitive condition after different attack times, latency and amplitude of P300, and detection rate of mild cognitive impairment. With the increase of the attack times, cognitive impairment aggravated gradually, and the detection rate of mild cognitive impairment increased gradually. Conclusions： Repeated TIAS have cumulative injtwy on cognitive function, The prevention and treatment of cerebral ischemia may become an important approach in decreasing cognitive impairment.